medline.ch Onkologie Magen-Darm

	Corrigendum to "Long-term exposure to fine particulate matter constituents and the prognosis of oral cancer patients: A prospective study in Southeastern China" [J Hazard Mater 487 (2025) 137304]. J Hazard Mater Hu P, Shen L, Chen G, Yang W, Ji Y, He B, Lin H. PMID: 42601240 [PubMed - as supplied by publisher]
	Efficacy of Probiotic and Synbiotic Supplementation on Antibiotic Use Duration and Risk of Postoperative Infection in Patients Undergoing Gastrointestinal and Cancer-Related Surgery: An Umbrella Review of Meta-Analyses. Clin Nutr ESPEN Zanganeh AH, Kia EM, Mehrabani S, Beikzadeh S, MacIsaac F, Mazinani K, Khosroshahi RA, Jalili F, Hojjati Kermani MA, Moradi S. PMID: 42600939 [PubMed - as supplied by publisher]
	Adjuvant oxaliplatin with S-1 (SOX) versus S-1 for stage II-III gastric cancer (CAPITAL): A randomized, open-label, phase 3 trial. Med Nie RC, Chen S, Wan J, Sun XW, Hong WQ, Wei HB, Wang W, Zhang WB, Zhao Y, Zhang WB, Chen JS, Wu ZG, Mai C, Feng CZ, Yuan SQ, Wang W, Qiu HB, Liang Y, Guan YX, Chen YM, Liu WW, Ding C, Peng JS, Chen YB, Zhou ZW, Li YF. PMID: 42600610 [PubMed - as supplied by publisher]
	PROGNOSTIC AND PREDICTIVE VALUE OF TUMOR BUDDING, LYMPHOVASCULAR INVASION, AND PERINEURAL INVASION IN COLORECTAL CARCINOMA ALTIN SALLAHU1, FERAT SALLAHU1. 1DEPARTMENT OF ABDOMINAL SURGERY, UNIVERSITY CLINICAL CENTER OF KOSOVO (UCCK), PRISHTINA, KOSOVO. ABSTRACT. BACKGROUND: COLORECTAL CARCINOMA (CRC) REMAINS ONE OF THE MOST COMMON MALIGNANCIES WORLDWIDE AND A LEADING CAUSE OF CANCER-RELATED MORTALITY. ACCURATE PREDICTION OF RECURRENCE IS ESSENTIAL FOR RISK STRATIFICATION AND INDIVIDUALIZED POSTOPERATIVE MANAGEMENT. THIS STUDY AIMED TO EVALUATE THE PROGNOSTIC AND PREDICTIVE SIGNIFICANCE OF TUMOR BUDDING (TB), LYMPHOVASCULAR INVASION (LVI), AND PERINEURAL INVASION (PNI) IN COLORECTAL CARCINOMA. METHODS: A RETROSPECTIVE COHORT STUDY WAS CONDUCTED INCLUDING PATIENTS TREATED AT THE CLINIC OF ABDOMINAL SURGERY AND THE DEPARTMENT OF PATHOLOGY, UNIVERSITY CLINICAL CENTER OF KOSOVO (UCCK), BETWEEN JANUARY 2020 AND JUNE 2025. FOLLOW-UP DATA COLLECTION CONTINUED UNTIL DECEMBER 2025, AND ONLY PATIENTS WITH A MINIMUM FOLLOW-UP DURATION OF 6 MONTHS WERE INCLUDED IN THE FINAL ANALYSIS. CLINICAL, SURGICAL, AND HISTOPATHOLOGICAL DATA WERE COLLECTED, INCLUDING TB, LVI, AND PNI STATUS. STATISTICAL ANALYSIS INCLUDED DESCRIPTIVE METHODS, CHI-SQUARE TEST, BINARY LOGISTIC REGRESSION, RECEIVER OPERATING CHARACTERISTIC (ROC) CURVE ANALYSIS WITH AREA UNDER THE CURVE (AUC), AND KAPLAN-MEIER DISEASE-FREE SURVIVAL (DFS) ANALYSIS WITH THE LOG-RANK TEST. RESULTS: HIGH TUMOR BUDDING (BD3) WAS IDENTIFIED IN 29.2% OF PATIENTS, LVI IN 34.1%, AND PNI IN 26.7%. AT LEAST ONE INVASIVE HISTOPATHOLOGICAL FACTOR WAS PRESENT IN 48.6% OF THE COHORT. ALL THREE MARKERS WERE SIGNIFICANTLY ASSOCIATED WITH DISEASE RECURRENCE (P < 0.001). MULTIVARIATE LOGISTIC REGRESSION DEMONSTRATED THAT INDEPENDENT PREDICTORS OF RECURRENCE WERE LVI (OR 4.72; 95% CI 2.46-9.03), PNI (OR 3.91; 95% CI 1.98-7.72), AND TB (OR 3.24; 95% CI 1.67-6.29). LVI SHOWED THE HIGHEST PREDICTIVE ACCURACY IN ROC ANALYSIS (AUC = 0.781). KAPLAN-MEIER SURVIVAL ANALYSIS DEMONSTRATED SIGNIFICANTLY SHORTER MEDIAN DISEASE-FREE SURVIVAL (DFS) IN PATIENTS WITH ONE OR MORE POSITIVE INVASIVE HISTOPATHOLOGICAL FACTORS COMPARED WITH PATIENTS WITHOUT SUCH FACTORS. MEDIAN DFS WAS 22.4 MONTHS (95% CI: 18.7-26.1) VERSUS 35.1 MONTHS (95% CI: 31.4-38.8), RESPECTIVELY (LOG-RANK P < 0.001) CONCLUSIONS: TUMOR BUDDING, LYMPHOVASCULAR INVASION, AND PERINEURAL INVASION ARE INDEPENDENT PROGNOSTIC MARKERS IN COLORECTAL CARCINOMA. AMONG THEM, LVI DEMONSTRATED THE STRONGEST PREDICTIVE VALUE FOR RECURRENCE. ROUTINE INCORPORATION OF THESE PARAMETERS INTO PATHOLOGICAL REPORTS MAY IMPROVE PROGNOSTIC ASSESSMENT AND SUPPORT THERAPEUTIC DECISION-MAKING. Georgian Med News Sallahu A, Sallahu F. PMID: 42600587 [PubMed - indexed for MEDLINE]
	Effectiveness of multitarget stool DNA versus faecal immunochemical testing alone in detecting colorectal cancer and advanced polyps: A systematic review. Cancer Epidemiol Lau J, Lim J, Lee M, Tan KK. PMID: 42600473 [PubMed - as supplied by publisher]
	Molecular functions, clinical correlates, and therapeutic prospects of B7-H3 expression in colorectal cancer: A systematic review. Cancer Treat Res Commun Alwisi N, Hamid M, Ghith D, Alshare S, Adham L, Sami S, Babu GR, Vrani. PMID: 42600349 [PubMed - as supplied by publisher]
	Editorial: Toward Prognostic Precision in the Management of Gastroenteropancreatic Neuroendocrine Neoplasms. Cancer Control Ergenç M, Yaz. PMID: 42599881 [PubMed - indexed for MEDLINE]
	Body Mass Index at Diagnosis, Prediagnostic Weight Loss, and Survival in Colorectal Cancer. JAMA Netw Open Mandic M, Wankhede D, Safizadeh F, Hoffmeister M, Brenner H. PMID: 42599706 [PubMed - indexed for MEDLINE]
	Beyond PERISCOPE II: Redesigning Peritoneal-Directed Treatment for Gastric Cancer. J Gastrointest Cancer Burke E. PMID: 42599601 [PubMed - indexed for MEDLINE]
	Radiomics for Prediction of Microsatellite Instability Status in Gastric Cancer: A Systematic Review and Meta-Analysis. J Gastrointest Cancer Gou Q, Wang K, He X, Zhang X. PMID: 42599597 [PubMed - indexed for MEDLINE]
	Early-Onset Colorectal Cancer in Neglected Populations: Would South Africa's Strategies Improve Screening, Management, and Genetic Insights Worldwide? J Racial Ethn Health Disparities Yildiz S, Rebello G, Ramesar R. PMID: 42599568 [PubMed - as supplied by publisher]
	Relative Dose Intensity and Clinical Outcomes of Using Trifluridine/Tipiracil with or without Bevacizumab in Patients Agedâ€‰â‰¥â€‰75 Years with Advanced or Recurrent Colorectal Cancer: a Single-Center Retrospective Study. J Gastrointest Cancer Tomiuchi A, Kimura M, Ikeda Y, Usami E. PMID: 42599544 [PubMed - indexed for MEDLINE]
	Nationwide Practice Patterns of Early Postoperative Kampo Medicine after Gastrectomy for Gastric Cancer: A Japanese Administrative Database Study. J Gastrointest Cancer Maruyama T, Ikezawa K, Suzuki H, Kurokawa T, Akashi Y, Oda T. PMID: 42599543 [PubMed - indexed for MEDLINE]
	Climate-sensitive exposures and cancer outcomes: a systematic review and meta-analysis. Int J Biometeorol Negahi A, Naseri A, Najdsepas H, Negahban H, Khosravi-Mashizi M, Alijanpour A, Narimani N, Atarod MM, Antikchi MH, Rahmani A, Neamatzadeh H. PMID: 42599337 [PubMed - indexed for MEDLINE]
	Ligation-assisted endoscopic mucosal resection versus endoscopic submucosal dissection for small gastrointestinal deep-layer lesions: A retrospective cohort study. J Int Med Res Zhang Q, Zhou Y, Pan P, Hu H, Xiao Z, Liu R, Zhang D, Tang A, Deng M, Wang X, Li J, Wang W. PMID: 42599210 [PubMed - indexed for MEDLINE]
	The Process of Adapting to Altered Bowel Function in Patients With Rectal Cancer: A Grounded Theory Study. Psychooncology Lu LC, Long A, Sun FK. PMID: 42599075 [PubMed - indexed for MEDLINE]
	Association between ABO blood group and survival in patients with esophageal, gastric, and colorectal cancer: a systematic review and meta-analysis. Eur J Cancer Prev Schena S, Nuvoli L, De Pascale S, Romario UF, Sileo A, Doccioli C, Di Maggio E, Palmieri G, La Vecchia C, Caini S, Gandini S. PMID: 42598881 [PubMed - as supplied by publisher]
	Prognostic Role of EMR1 in Lymph Nodes and Primary Tumors of Colon Cancer Patients. Adv Biol (Weinh) Roshdy T, Eltorky H, Mohamed A, Zahran F, Guirgis A, Olsson L, Lindmark G, Hammarström ML, Hammarström S, Sitohy B. PMID: 42598774 [PubMed - indexed for MEDLINE]
	Amentoflavone and cancer: mechanistic insights and translational perspectives. Front Oncol Hashida H, Kobayashi A, Akagami M, Okamoto T, Tanaka H. PMID: 42598615 [PubMed]
	Psychological distress as a putative host-state determinant of cancer immunotherapy response. Front Immunol Bronisz A, Kiel K, Godlewski J. PMID: 42598069 [PubMed - indexed for MEDLINE]

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