medline.ch Gastroenterologie

	Novel triglyceride-lowering therapies to reduce the risk of acute pancreatitis in hypertriglyceridaemia: a protocol for systematic review and meta-analysis. BMJ Open Wu Y, Liu S, Luo W, Rao J, He W, Windsor J, Sutton R, Mukherjee R, Shi N, Huang W. PMID: 42601105 [PubMed - indexed for MEDLINE]
	Association of caffeine citrate administration with necrotising enterocolitis in infants < 32 weeks' gestation: a retrospective cohort study. BMJ Open Hu X, Yuan L, Wang Q, Zhu L, Dang D, Fu Y, Gong H, Han S, Yang J, Chinese Neonatal Network. PMID: 42601100 [PubMed - indexed for MEDLINE]
	Biopsy-confirmed acute Q fever hepatitis complicating severe alcohol-associated hepatitis: a diagnostic and management challenge. BMJ Case Rep Ismail AGM, Gunawardena D, Chin J. PMID: 42601077 [PubMed - indexed for MEDLINE]
	THE POTENTIAL HEPATOPROTECTIVE EFFECT OF PALMITOLEIC ACID AGAINST KETAMINE-INDUCED LIVER INJURY IN RATS: OXIDATIVE, INFLAMMATORY, AND HISTOPATHOLOGICAL EVALUATION. Georgian Med News Rafeeq F, Al-Thanoon Z. PMID: 42600605 [PubMed - indexed for MEDLINE]
	EFFECTIVENESS OF PLASMA EXCHANGE IN THE THERAPY OF DRUG-INDUCED HEPATITIS IN PATIENTS WITH PULMONARY TUBERCULOSIS AND CHRONIC VIRAL HEPATITIS B AND C. Georgian Med News Kurmangaliyeva K, Shlymova R, Askarova K, Darybayeva A, Kazangapova A, Sagyndykova G, Yeshmagambetova Z, Akhmedyarova E. PMID: 42600602 [PubMed - indexed for MEDLINE]
	ASSOCIATION BETWEEN THYROID HORMONE LEVELS AND ADVANCED LIVER FIBROSIS IN PATIENTS WITH TYPE 2 DIABETES MELLITUS AND NON-ALCOHOLIC FATTY LIVER DISEASE. Georgian Med News Omer S, Elkhalifa A, Abdrabo A, Osman E. PMID: 42600592 [PubMed - indexed for MEDLINE]
	PROGNOSTIC AND PREDICTIVE VALUE OF TUMOR BUDDING, LYMPHOVASCULAR INVASION, AND PERINEURAL INVASION IN COLORECTAL CARCINOMA ALTIN SALLAHU1, FERAT SALLAHU1. 1DEPARTMENT OF ABDOMINAL SURGERY, UNIVERSITY CLINICAL CENTER OF KOSOVO (UCCK), PRISHTINA, KOSOVO. ABSTRACT. BACKGROUND: COLORECTAL CARCINOMA (CRC) REMAINS ONE OF THE MOST COMMON MALIGNANCIES WORLDWIDE AND A LEADING CAUSE OF CANCER-RELATED MORTALITY. ACCURATE PREDICTION OF RECURRENCE IS ESSENTIAL FOR RISK STRATIFICATION AND INDIVIDUALIZED POSTOPERATIVE MANAGEMENT. THIS STUDY AIMED TO EVALUATE THE PROGNOSTIC AND PREDICTIVE SIGNIFICANCE OF TUMOR BUDDING (TB), LYMPHOVASCULAR INVASION (LVI), AND PERINEURAL INVASION (PNI) IN COLORECTAL CARCINOMA. METHODS: A RETROSPECTIVE COHORT STUDY WAS CONDUCTED INCLUDING PATIENTS TREATED AT THE CLINIC OF ABDOMINAL SURGERY AND THE DEPARTMENT OF PATHOLOGY, UNIVERSITY CLINICAL CENTER OF KOSOVO (UCCK), BETWEEN JANUARY 2020 AND JUNE 2025. FOLLOW-UP DATA COLLECTION CONTINUED UNTIL DECEMBER 2025, AND ONLY PATIENTS WITH A MINIMUM FOLLOW-UP DURATION OF 6 MONTHS WERE INCLUDED IN THE FINAL ANALYSIS. CLINICAL, SURGICAL, AND HISTOPATHOLOGICAL DATA WERE COLLECTED, INCLUDING TB, LVI, AND PNI STATUS. STATISTICAL ANALYSIS INCLUDED DESCRIPTIVE METHODS, CHI-SQUARE TEST, BINARY LOGISTIC REGRESSION, RECEIVER OPERATING CHARACTERISTIC (ROC) CURVE ANALYSIS WITH AREA UNDER THE CURVE (AUC), AND KAPLAN-MEIER DISEASE-FREE SURVIVAL (DFS) ANALYSIS WITH THE LOG-RANK TEST. RESULTS: HIGH TUMOR BUDDING (BD3) WAS IDENTIFIED IN 29.2% OF PATIENTS, LVI IN 34.1%, AND PNI IN 26.7%. AT LEAST ONE INVASIVE HISTOPATHOLOGICAL FACTOR WAS PRESENT IN 48.6% OF THE COHORT. ALL THREE MARKERS WERE SIGNIFICANTLY ASSOCIATED WITH DISEASE RECURRENCE (P < 0.001). MULTIVARIATE LOGISTIC REGRESSION DEMONSTRATED THAT INDEPENDENT PREDICTORS OF RECURRENCE WERE LVI (OR 4.72; 95% CI 2.46-9.03), PNI (OR 3.91; 95% CI 1.98-7.72), AND TB (OR 3.24; 95% CI 1.67-6.29). LVI SHOWED THE HIGHEST PREDICTIVE ACCURACY IN ROC ANALYSIS (AUC = 0.781). KAPLAN-MEIER SURVIVAL ANALYSIS DEMONSTRATED SIGNIFICANTLY SHORTER MEDIAN DISEASE-FREE SURVIVAL (DFS) IN PATIENTS WITH ONE OR MORE POSITIVE INVASIVE HISTOPATHOLOGICAL FACTORS COMPARED WITH PATIENTS WITHOUT SUCH FACTORS. MEDIAN DFS WAS 22.4 MONTHS (95% CI: 18.7-26.1) VERSUS 35.1 MONTHS (95% CI: 31.4-38.8), RESPECTIVELY (LOG-RANK P < 0.001) CONCLUSIONS: TUMOR BUDDING, LYMPHOVASCULAR INVASION, AND PERINEURAL INVASION ARE INDEPENDENT PROGNOSTIC MARKERS IN COLORECTAL CARCINOMA. AMONG THEM, LVI DEMONSTRATED THE STRONGEST PREDICTIVE VALUE FOR RECURRENCE. ROUTINE INCORPORATION OF THESE PARAMETERS INTO PATHOLOGICAL REPORTS MAY IMPROVE PROGNOSTIC ASSESSMENT AND SUPPORT THERAPEUTIC DECISION-MAKING. Georgian Med News Sallahu A, Sallahu F. PMID: 42600587 [PubMed - indexed for MEDLINE]
	A RARE PRESENTATION OF DIFFUSE LARGE B-CELL LYMPHOMA AS SEVERE ACUTE HEPATITIS AND SECONDARY HEMOPHAGOCYTIC LYMPHOHISTIOCYTOSIS IN A YOUNG ADULT: A CASE REPORT. Georgian Med News Abdelhadi M, Alhendi M, AlShowaiker K, Almaimooni A, Aljenaee K, Hajji S, Eldamarawy R, Shalaby N. PMID: 42600579 [PubMed - indexed for MEDLINE]
	On the History of Hepatic Vein Catheterization. Liver Int Henriksen JH, Bendtsen F, Møller S. PMID: 42599960 [PubMed - indexed for MEDLINE]
	Burden of Shigella infection in children under five years living in a peri-urban area of Ouagadougou, Burkina Faso: A community-based cohort study. PLoS Negl Trop Dis Héma A, Sawadogo J, Soulama BI, Hien D, Diarra A, Sermé SS, Ouédraogo AZ, Nébié I, Houard S, Ouédraogo A, Tiono AB, Sanou M, Sirima SB. PMID: 42599952 [PubMed - indexed for MEDLINE]
	Endotrophin Measured by PRO-C6 as a Prognostic Biomarker for Liver-Related Events in Patients With Advanced Chronic Liver Disease. Liver Int Wiggers T, Skovgaard ET, Karsdal M, Holst JJ, Christiansen F, de Zawadzki A, Leeming DJ, Patel K. PMID: 42599924 [PubMed - indexed for MEDLINE]
	Association between gallstones and subclinical coronary atherosclerosis: An observational study with propensity score matching. PLoS One Kim S, So H, Park HW, Park S, Lee SB, Ann SH, Hwang SW, Jeon YJ, Park EJ, Kwon WJ, Choi SH, Jung SW, Bang SJ, Park GM. PMID: 42599905 [PubMed - indexed for MEDLINE]
	Editorial: Toward Prognostic Precision in the Management of Gastroenteropancreatic Neuroendocrine Neoplasms. Cancer Control Ergenç M, Yaz. PMID: 42599881 [PubMed - indexed for MEDLINE]
	Geospatial Discrepancy of Chronic Hepatitis B and Hepatitis D Testing in Alberta: A Population-Based Spatial Analysis. J Viral Hepat Tkachuk B, Couloigner I, Coffin CS, Jiang J, Bertazzon S, Shaheen AA. PMID: 42599847 [PubMed - indexed for MEDLINE]
	Body Mass Index at Diagnosis, Prediagnostic Weight Loss, and Survival in Colorectal Cancer. JAMA Netw Open Mandic M, Wankhede D, Safizadeh F, Hoffmeister M, Brenner H. PMID: 42599706 [PubMed - indexed for MEDLINE]
	The LKB1-AMPK pathway in NAFLD: molecular mechanisms and therapeutic implications. J Physiol Biochem Goleij P, Tabari MAK, Naser Y, Alataa R, Osman MAM, Rezaee A, Aschner M, Ahmed ARD, Safrah MA, Khan H. PMID: 42599615 [PubMed - indexed for MEDLINE]
	Beyond PERISCOPE II: Redesigning Peritoneal-Directed Treatment for Gastric Cancer. J Gastrointest Cancer Burke E. PMID: 42599601 [PubMed - indexed for MEDLINE]
	Radiomics for Prediction of Microsatellite Instability Status in Gastric Cancer: A Systematic Review and Meta-Analysis. J Gastrointest Cancer Gou Q, Wang K, He X, Zhang X. PMID: 42599597 [PubMed - indexed for MEDLINE]
	Hepatic stellate cells in alcoholic liver cirrhosis: mechanisms of fibrogenesis, plasticity, and fibrosis reversal. Daru Raj A, Kosey S. PMID: 42599594 [PubMed - indexed for MEDLINE]
	Relative Dose Intensity and Clinical Outcomes of Using Trifluridine/Tipiracil with or without Bevacizumab in Patients Agedâ€‰â‰¥â€‰75 Years with Advanced or Recurrent Colorectal Cancer: a Single-Center Retrospective Study. J Gastrointest Cancer Tomiuchi A, Kimura M, Ikeda Y, Usami E. PMID: 42599544 [PubMed - indexed for MEDLINE]

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